Grants Awarded to CVM Faculty 2018

If you have received external or internal (U of M) research-related funding please complete this form to notify the CVM Research Office. We are striving to announce new awards in an effort to recognize the many research accomplishments of CVM faculty.  You may also use this form to contact the Research Office to request a correction of details concerning funding currently listed or to provide feedback.


OCTOBER 2018

Principal Investigator: Fabio Vannucci
Title: Characterization of the local and systemic immune response to Lawsonia intracellularis infction after oral and injectable vaccination
Funding Agency: Boehringer Ingelheim Vetmedica, Inc
Duration: 10/1/2018-9/30/2019
Amount: $65,318

Principal Investigator: Montserrat Torremorell, VPM
Title: Using genomic tools to link PRRSV quasispecies to disease severity in pigs infected with contemporary virulence islates.
Funding Agency: National Pork Board
Duration: 10/1/2018-9/30/2019
Amount: $49,969

Principal Investigator: Mike Conzemius, VCS
Title: A Pilot Field Study to Evaluate the Efficacy and Clinical Safety of Intra-articular TPX-100 in Dogs with Elbow Osteoarthritis
Funding Agency: Elanco Animal Health
Duration: 10/5/2018-12/30/202o
Amount: $596,437


 SEPTEMBER 2018

Principal Investigator: Fabio Vannucci, VPM
Title:
 Evaluation of Carrier State and Protection Against a Contemporary Senecavirus A Isolate in Pigs Previously Infected with a Historical Strain 
Funding Agency: 
National Pork Board 
Duration: 
9/1/2018-8/31/2019
Amount: $95,847

Principal Investigator: Cesar Corzo, VPM
Title:
Characterization of United States Breeding-Stock Companies International Transport Biosecurity Practices 
Funding Agency: 
Swine Health Information Center, Inc.
Duration: 
9/01/2018-3/31/2019
Amount: 
$23,816

Principal Investigator: Sheila Torres, VCS
Title: Safety and Efficacy of a Piperidine-Based, Reversible Inhibitor of Acetylcholinesterase in Client-Owned Dogs with Atopic Dermatitis
Funding Agency: Neuroderma LLC
Duration: 9/1/2018-8/31/2019
Amount: $26,543

Principal Investigator: Noelle Noyes, VPM
Title: Catalyzing an open-community research and education program to leverage the microbiome for the advancement of organic livestock production using mastitis as a test case.
Funding Agency: USDA NIFA
Duration: 9/1/2018-8/31/2021
Amount: $1,572,908

Mastitis is the most commonly-reported disease in organic dairy production systems, and nearly 95% of organic dairy producers report a need for additional research into novel and effective strategies for prevention and treatment of mastitis. Failure to control mastitis can lead to devastating economic, animal welfare and even food safety consequences. Organic producers are in a particularly difficult situation with regard to preventing and treating mastitis, as most evidence-based mastitis protocols involve use of antibiotics, which are not allowed for use in organic production. Furthermore, recent studies indicate that the vast majority of organic producers already employ the most efficacious mastitis prevention strategies, including forestripping, predipping and postdipping. Taken together, these survey results indicate that most organic dairy producers have exhausted existing strategies and are in critical need of new tools for preventing and treating mastitis. This proposal addresses this critical need by systematically and strategically investigating the most promising yet complex tool at our disposal: the microbiome, i.e., the collection of microbes that reside in, on and around us. Results from the human literature suggest that microbiome-based therapies are likely to be the next frontier in treating skin-related disorders. Unfortunately, the literature pertaining to cow health and the udder

microbiome is extremely small, and there is a critical shortage of microbiome data from organically-reared dairy cows, particularly relating to udder health. This shortage is preventing the organic community from benefiting from microbiome-related advances. This proposal addresses this shortage by not only generating a large amount of publically available microbiome data, but also by developing an open-source, curated repository for continuously-generated microbiome-related data, specifically for use by the organic community.

Principal Investigator: Pamela Skinner, VBS
Title: BELIEVE
Funding Agency: NIH Prime (Joan & Sanford) Weill Medical College
Duration: 9/1/2018-8/31/2021
Amount: $334,831

Principal Investigator: Jaime Modiano, VCS
Title: Mechanisms of Resistance to Immunotherapy in Osteosarcoma
Funding Agency: US Department of Defense
Duration: 9/1/2018-8/31/2020
Amount: $615,579

Principal Investigator: Larissa Minicucci, VPM
Title: CWD Testing of Hunter Killed Deer 2018
Funding Agency: MN Department of Natural Resources
Duration: 9/12/2018-12/31/2018
Amount: $77,580

Principal Investigator: Jerry Torrison, VPM
Title: Method Development and Validation of Oxford Nanopore MinION for Whole Genome Sequencing of Salmonella Species
Funding Agency: DHHS Food & Drug Administration
Duration: 9/12/2018-8/31/2018
Amount: $29,210

Principal Investigator: Albert Rovira, VPM
Title: Investigation of the clinical signs and lesions associated with PCV3
Funding Agency: Swine Health Information Center, Inc
Duration: 9/15/2018-9/14/2019
Amount: $14,325

Principal Investigator: Pedro Urriola
Title: Building of a HARPC framework and use of blockchain technology to evaluate and minimize risk of transmission of foreign viruses in imported animal feed ingredients.
Funding Agency: Swine Health Information Center, Inc
Duration: 9/15/2018-1/15/2019
Amount: $54,413

Principal Investigator: Molly McCue, VPM
Title: Summer Scholar Investigating genetic bases for recurrent exertional rhabdomyolysis (tying up) in horses
Funding Agency: MN Racing Commission
Duration: 9/18/2018-5/24/2019/2019
Amount: $5,000

Principal Investigator: Wanda Gordon-Evans, VCS
Title: Study C181C-US-17-065 Field Safety and Efficacy of ZTS-00084768 Compared to Placebo for the Treatment of Pain Associated with Osteoarthritis in Cats
Funding Agency: Archerabio, LLC (Zoetic, Inc: Prime)
Duration: 9/19/2018-9/18/2019
Amount: $44,819

Principal Investigator: Carol Cardona, VBS
Title: Risk Analysis & Modeling HPAI & Other Animal Disease Emergencies
Funding Agency: USDA APHIS Animal & Plant Inspection
Duration: 9/24/2018-9/23/2019
Amount: $172,000

This project is a collaboration between the Center for Epidemiology and Animal Health (CEAH) and the University of Minnesota (UMN). The collaboration focuses on assessing risks associated with different disease management options for mitigating and rapidly controlling outbreaks of HPAI and other rapidly transmitted diseases of poultry and livestock. Assessments are targeted to solve specific problems VS faces during outbreaks and contribute to the development of guidance documents for clear communication of technical results to state animal health officials and other stakeholders. This specific project will result in assessments that

A) optimize on-farm surveillance design for varying AI pathogenicity and transmission characteristics (related to disease detection and determining most likely time of disease introduction), varying test characteristics (including sensitivity, specificity, and timing of testing for detection), and poultry production types, and
B) provide defensible estimates of the likelihood of spreading AI and other viruses when implementing management options within a control zone, such as carcass disposal, egg movement, and controlled marketing, and
C) perform modeling as needed to address key risk management questions (e.g., rendering as a disposal option) as well as to perform short turn around analyses as requested by stakeholders during disease outbreaks.

Principal Investigator: Montserrat Torremorell, VPM
Title: Using genomic tools to link PRRSV quasispecies to disease severity in pigs infected with contemporary virulence islates.
Principal Investigator: Julie Ponder, VPM
Title: Review of non-target mitigation plan for Midway Seabird Restoration Project
Funding Agency: Island Conservation
Duration: 9/25/2018-12/25/2018
Amount: $3,504

Principal Investigator: Cesar Corzo, VPM
Title: Secure Food Systems Team Contract with Minnesota Board of Animal Health
Funding Agency: Minnesota Board of Animal Health
Duration: 9/28/2018-6/30/2019
Amount: $39,058 


AUGUST 2018

Principal Investigator: Dominic Travis, VPM
Title: 
Evidence-Based Approach to Health Management in PASA Sanctuaries 
Funding Agency: 
Arcus Foundation
Duration: 
8/1/2018-7/31/2021
Amount: $631,861

Principal Investigator: Randall Singer, VBS
Title:
Longitudinal On-Farm Broiler AMR Investigation in California 
Funding Agency:
California Department of Food & Agriculture 
Duration:
8/1/2018-9/30/2020
Amount: 
$467,983

Principal Investigator: Sandra Godden, VPM
Title: Selective Dry Cow Therapy on US Dairy Farms Impact on Udder Health
Funding Agency: USDA NIFA
Duration: 8/1/2018-7/31/2020
Amount: $498,500
Project Abstract

Principal Investigator: Matthew Aliota, VBS
Title: Zika virus pathophysiology during pregnancy
Funding Agency: NIH Prime (subcontract for University of Wisconsin – Madison)
Duration: 8/01/2018-/2018-7/31/2019
Amount: $20,667

Principal Investigator: Bruce Walcheck, VBS
Title:
Enhancing the Function of CD16a in Natural Killer Cells to Improve Tumor Cell Killing 
Funding Agency: Howard Hughes Medical Institute 
Duration: 8/13/2018-8/12/2019
Amount: $43,000

Principal Investigator: Jennifer Granick, VCS
Title: Text CP-739-Feline FACTS
Funding Agency: Hill’s Pet Nutrition, Inc
Duration: 8/15/2018-12/31/2019
Amount: $16,670

Principal Investigator: Scott Wells, VPM
Title: Assessment of Chronic Wasting Disease Transmission to Minnesota Farmed Cervids
Funding Agency: Minnesota Board of Animal Health
Duration: 8/31/2018-6/30/2019
Amount: $58,722


JULY 2018

Principal Investigator: Sheila Torres, VCS
Title:
A Field Study Investigating the Efficacy of Two Dose Levels of an Anti-IL-31 Monoclonal Antibody (IL-31 mAb) for Treatment of Allergic Dermatitis in Client-Owned Cats 
Funding Agency: Alcherabio, LLC 
Duration: 7/1/2018-6/30/2019
Amount: $49,613

Principal Investigator: Kimberly VanderWaal, VPM 
Title: An Early Warning System for Wildlife Health Threats Using Wildlife Rehabilitation Data to Monitor Wildlife Health 
Funding Agency: Legislative-Commission on Minnesota Resources (LCCMR)
Duration: 07/01/2018-06/30/2020
Amount: $280,000.00

Principal Investigator: Jerry Torrison, VDL
Title: MN NAHLN FY18 Member Lab Agreement
Funding Agency: USDA APHIS
Duration: 7/15/2018-7/14/2019
Amount: $328,000

Principal Investigator: Eva Furrow, VCS
Title:
Investigation of a Genetic Immunodeficiency in Miniature Schnauzers 
Funding Agency: Gray Lady Foundation, Inc.
Duration: 7/17/18-7/16/19
Amount: $7,210.00

Principal Investigator: Timothy Johnson, VBS
Title: Mitigation of Antibiotic Resistance in Poultry Through Resensitization, Vaccination, and Microbial Restoration 
Funding Agency: USDA NIFA 
Duration: 7/1/2018-6/30/2022
Amount: $1,199,602.00

Principal Investigator: Randall Singer, VBS
Title:
Defining Minnesota's Environmental Antibiotic and Antibiotic Resistance Footprint
Funding Agency: Legislative-Commission on Minnesota Resources (LCCMR)
Duration: 7/1/2018-6/30/2021
Amount: $750,000

Principal Investigator: Bruce Walcheck, VBS
Title:
Engineered Natural Killer Cells Expressing Chimeric CD64 as a Cancer Immunotherapy 
Funding Agency: Minnesota Ovarian Cancer Alliance
Duration: 7/1/2018-6/30/2019
Award Amount: $100,000


JUNE 2018

Principal Investigator: Kakambi Nagaraja, VBS
Title:
Evaluate Safety and Efficacy of a Live Temperature Sensitive (Ts) Mutant Ornithobacterium Rhinotracheale Vaccine for Use in Turkeys in the Field 
Funding Agency:
USDA NIFA Prime (Subcontract from The Ohio State University)
Duration: 
6/1/2018-5/31/2019
Award Amount: 
$50,000

Principal Investigator: Emily Walz, VBS
Title: This is How We Role: Inspiring Future Researchers through Veterinary Medicine
Funding Agency: National Institute of Health Prime (Sucontract from Purdue University)
Duration: 6/1/2018-4/30/2019
Amount: $5,000

Principal Investigator: Matthew Aliota, VBS
Title:
Zika Virus Evolutionary Dynamics in Host Adaption 
Funding Agency: NIH, National Institute of Allergy and Infectious Disease
Duration: 6/15/2018-1/31/2019
Award Amount: $192,500

Principal Investigator: Matthew Aliota, VBS
Title: Previous Exposure to Dengue as a Risk Factor for Zika During Pregnancy 
Funding Agency: NIH, National Institute of Allergy and Infectious Disease 
Duration: 6/1/2018-12/31/2022
Award Amount: $273,577

Principal Investigator: Sandra Godden, VPM
Title:
Randomized Equivalence Study Evaluating the Efficacy of Two Commercial Internal Teat Sealants in Dairy Cows 
Funding Agency: Boehringer Ingelheim Vetmedica, Inc. 
Duration: 6/1/2018-5/30/2019
Award Amount: $54,483

Principal Investigator: Michael Murtaugh, VBS
Title: Rapid, Pen-Side Molecular Diagnostic Tool for Foreign Animal Disease
Funding Agency: National Pork Board
Duration: 6/1/2018-5/31/2020
Award Amount: $139,580

The proposed research is to develop and benchmark methods and protocols for pen-side sequencing for vesicular disease diagnostics that can provide producers with new options for real-time rapid molecular detection of foreign and endemic pathogens. Findings will be broadly applicable to a wide range of health applications in swine production.

Principal Investigator: Steven Friedenberg, VCS
Title: Identification of Genetic Variants Associated with the Development and Severity of Myxomatous Mitral Valve Disease in the Small Breed Dog 
Funding Agency: North Carolina State University (Subcontract).
Prime Funding Agency: Morris Animal Foundation 

Duration: 6/1/2018-2/28/2019
Award Amount: $2,948


MAY 2018

Principal Investigator: P. Srirama Rao, VBS
Title: Role of TrkA in Airway Allergic Inflammation
Funding Agency: National Institutes of Health, NIAID (R21)
Duration: 5/1/2018-4/30/2018
Award Amount: $423,500
The objective of this proposal is to understand the mechanism by which Tropomyosin receptor kinase (Trk) A, a member of the Trk family of receptor tyrosine kinases and the high- affinity receptor for nerve growth factor, regulates airway allergic inflammation.  

Principal Investigator: Cesar Corzo, VPM 
Title: Estimating Prevalence of Senecavirus A (Antibodies in Oral Fluid Specimens in the US Swine Industry)
Funding Agency: National Pork Board
Duration: 5/1/2018-4/30/2019
Amount: $95,527

Principal Investigator: Maria Pieters, VPM 
Title: Effects of Early-Life Antibiotic Administration on Porcine Respiratory Microbiota and Piglet Immunity 
Funding Agency: National Pork Board 
Duration: 5/1/2018-4/30/2019
Amount: $71,173

Principal Investigator: Maria Pieters, VPM 
Title: A Model to Evaluate Mycoplasma Hyopneumoniae Early Detection and Transmission Dynamics in Minimal Prevalence Scenarios
Funding Agency: Minnesota Pork Board
Duration: 5/01/2018-4/30/2019
Amount: $66,809.00

Principal Investigator: Yinduo Ji, VBS
Title: Role of GM-CSF in Impaired Microphage Clearance of Mycobaterium Abcessus
Funding Agency: Cystic Fibrosis Foundation 
Duration: 5/1/2018-4/30/2019
Award Amount: $54,000

Principal Investigator: Declan Schroeder, VPM
Title: ReVive Rolling out the Evolution of resistance to Varroa and DWV
Funding Agency: Bee Diseases Insurance, Ltd
Duration: 5/1/2018-10/31/2019
Amount: $27,300

Principal Investigator: Maxim Cheeran, VPM 
Title: 
Analysis of Cellular Immunity Following Vaccination with PCV2/M.Hyo Combination Products or an M.Hyo Monovalent Product (Clinical Trial)
Funding Agency: Pharmgate Biologics Inc. 
Duration: 5/11/18-8/11/18
Award Amount: $23,000

Mcyoplasma hyopneumoniae is a respiratory pathogen causing chronic pneumonia in pigs and plays a significant role in the Porcine Respiratory Disease Complex. This proposal will complement a Pharmgate biologicals proposal and will assess My. Hyopneumoniae-species specific T cell response in piglets after immunization with various commercial vaccines. 

Principal Investigator: Tiffany Wolf, VPM (Mentor)
Student Scholar: Treana Mayer
Title: Quantifying Larval Epidemiology of the meningeal Worm (Parleaphostrongylus Tenuis)
Funding Agency: Morris Animal Foundation
Duration: 5/1/2018-8/31/2018
Award Amount: $5,000

This veterinary student scholars grant proposal aims to develop a PCR approach to measure the shedding rates of larvae in a fecal sample and to describe the within-host genetic heterogeneity of the meningeal worm larvae to infer adult worm burden. In addition to creating a more rapid prevalence test, this study has the potential to examine the relatedness of P. tenuis across Minnesota to gain further insight into the parasite’s spread through the landscape. This will be a novel application of landscape genetics to study the ecology and epidemiology of a nematode parasite and could inform the application of qPCR for other multi-host parasites of serious consequence. 

Principal Investigator: Eva Furrow, VCS
Student Researcher
: Nicole Wanner, VCS
Title: Uncovering the Genetic Basis for a Juvenile Polyneuropathy in Siberian Husky Dogs
Funding Agency: International Sled Dog Veterinary Medical Association
Duration: 5/28/2018-11/27/2019
Award Amount: $4,000

Student Research grant to investigate the inheritance of a debilitating neurologic disease in a population of young dogs bred for sled racing using genome-wide association and genome sequencing techniques. 


APRIL 2018

Principal Investigator: Kimberly VanderWaal, VPM
Title: Forecasting the Spread of Endemic Viruses of Swine in the United States
Funding Agency: USDA NIFA AFRI CARE
Duration: 4/1/18-8/31/2020
Amount: $300,000

Principal Investigator: Molly McCue, VPM 
Title: Determining the Role of Diet in Insulin Dysregulation in Horses and Ponies: A Metabolomic and Microbiomic Analysis
Funding Agency: Morris Animal Foundation 
Duration: 04/1/2018-03/31/2020
Award Amount: $55,308

Principal Investigator: Steven Friedenberg, VCS
Title: Whole Blood Transcriptome Profiling of Dogs with Immune-Mediated Hemolytic Anemia (IMHA)
Funding Agency: American Kennel Club, Canine Health Foundation
Duration: 4/1/18-3/31/20
Award Amount: $53,741

Principal Investigator: Timothy J. Johnson, VBS
Title: Ornithobacterium Rhinotracheale (ORT): Re-assessing Vaccine Efficacy and Understanding Pathogen Efficacy 
Funding Agency: Minnesota Turkey Research and Promotion Council 
Duration: 4/1/2018-3/31/2019
Award Amount: $40,000

Principal Investigator: Sunil Kumar, VPM
Title: Turkey Arthritis Reovirus Solutions
Funding Agency: Minnesota Turkey Research and Promotion Council
Duration: 4/1/18-3/31/19
Award Amount: $30,700

Principal Investigator: Alonso Guedes, VCS
Title: Role of Cyclooxygenase and Soluble Epoxide Hydrolase Branches of Lipid Metabolism in Peripheral Tissue Responses to Inflammatory Challenge
Funding Agency: Grayson Jockey Association
Duration: 4/1/2018-3/31/2019
Amount: $23,043

Principal Investigator: Luciano Caixeta, VPM
Title: Use of a Bovine Non-Specific Immune Stimulant on Health and Performance of Jersey Calves During the Pre-Weaning Period
Funding Agency: American Jersey Cattle Association
Duration: 4/1/18-3/31/19
Amount: $9,218


MARCH 2018

Principal Investigator: Montse Torremorell, VPM
Title: Shedding of Live Attenuated Influenza Vaccine (LAIV) Inglevac Provenza Under Field Conditions
Funding Agency: Boehringer Ingelheim Vetmedica, Inc.
Duration: 2/23/18-2/22/19
Amount: $63,440

Principal Investigator: Juan Sanhueza, VPM
Title: Evaluation of Parity as Delaying Factor to Reach PRRSV
Funding Agency: Boehringer Ingelheim Vetmedica, Inc. 
Duration: 3/1/2018-2/28/2019
Award Amount: $35,000

Principal Investigator: Sheila Torres, VCS
Title: Dose Determination Study Using Ceragenin-Based Cream to Treat Canine Superficial Pyoderma - A Randomized Double-Blind, Placebo-Controlled Clinical Trial
Funding Agency: CSA Biotech 
Duration: 3/19/2018-3/18/2019
Amount: $24,300

Principal Investigator: Perle Boyer, VPM
Title: Development of Day 1 Competencies for Swine Veterinary Graduates 
Funding Agency: American Association of Swine Veterinarians
Duration: 3/10/2018-3/9/2019
Amount: $9,000


FEBRUARY 2018 

Principal InvestigatorMontse Torremorell, VPM 
Title: Shedding of Live Attenuated Influenza Vaccine (LAIV) Inglevac Provenza Under Field Conditions
Funding Agency: Boehringer Ingelheim Vetmedica, Inc.
Duration: 2/23/18-2/22/19
Amount: $63,440


JANUARY 2018

Principal Investigator: Julia Ponder, VPM 
Title: Improving Animal Welfare in Wildlife Rehabilitation 
Funding Agency: Funded through foundation and philanthropic grants
Duration: 1/1/2018-6/30/2021
Award Amount: $3,710,000

Principal Investigator: Timothy J. Johnson, VBS
Title: Antimicrobial Resistance Transmission Associated with Small-Scale Food-Animal Production in Peri-Urban Communities of Quito, Ecuador
Funding Agency: Public Health Institute (Subaward of NIH)
Duration: 1/1/2018-12/31/2021
Award Amount: $444,081

Principal Investigator: Steven Friedenberg, VCS
Title: Identifying the Disease-Defining Autoantibodies in Canine Addison's Disease 
Funding Agency: American Kennel Club (Co-Sponsored by the Portuguese Water Dog Foundation)
Duration: 01/01/2018-6/30/2020
Award Amount: $181,864
More Information 

Principal Investigator: Fabio Vannucci, VPM
Title: Senecavirus A in Sows: Impact of Transportation Stress on Early Development Of Vesicular Lesions, Transmission, and Recurrence
Funding Agency: National Pork Board
Duration: 01/1/2018-5/31/2019
Award Amount: $110,179
The overall goal of this project is to determine the role of transportation stress on the early development of vesicular lesions, transmission and recurrence of clinical disease in sows experimentally infected with Senecavirus A.

Principal Investigator: Timothy O’Brien, VBS
Title: Brain Organoid Cell Products for Research and Therapeutic Applications
Funding Agency: National Science Foundation
Duration: 1/1/2018-6/30/18
Award Amount: $50,000

Principal Investigator: Pamela Skinner, VBS
Title: An IL-15 Superagonist Approach to Clear the Latent Viral Reservoir
Funding Agency: Oregon Health and Science University (NIH Subaward) 
Duration: 1/1/2018-12/31/2019
Award Amount: $29,899

Principal Investigator: Jim Mickelson, VBS
Title: Basis of Dwarfism in Great Pyrenees
Funding Agency: AKC Canine Health Foundation
Duration: 1/1/18-12/31/18
Award Amount: $14,915

Principal Investigator: Troy Trumble, VPM
Title: Optimizing physical activity for knee joint health after ACL reconstruction
Funding Agency: Health Partners Institute for Education and Research
Duration: 01/01/2018-12/31/2019
Amount: $328,000