Department of Veterinary and Biomedical Sciences
Jianming (Jimmy) Wu Publishes in the Intl Journal of Molecular Sciences
This paper "Human Leukocyte Antigen C*12:02:02 and Killer Immunoglobulin-Like Receptor 2DL5 are Distinctly Associated with Ankylosing Spondylitis in the Taiwanese," reports strong genetic roles of human leukocyte antigen C (HLA-C) and killer immunoglobulin-like receptors (KIR) in the development of ankylosing spondylitis, which is a debilitating arthritis involving spine.
Dr. Wu's research identified a specific HLA-C allele as the strongest risk factor for ankylosing spondylitis in Taiwanese (the odds ratio is about 17). They also discovered several KIR genotypes are strongly associated with ankylosing spondylitis.