Clinical Investigation Center

Current Clinical Trials

We have many opportunities for pet animals to participate in clinical trials. Each listing below has a quick summary plus a link to more information for each study.

Clinical Trials Seeking Participants

Cancer (Oncology)

Cancer (Oncology)

Dogs with hemangiosarcoma (HSA) - autologous vaccine

Dogs diagnosed with hemangiosarcoma of the spleen or liver scheduled for surgery at the VMC (splenectomy or lobectomy) for a clinical trial of an autologous vaccine (made from the dog's own tumor cells)

Learn more about Autologous vaccine for immunotherapy of hemangiosarcoma

Dogs with hemangiosarcoma and residual disease - chemo agent trial

Dogs diagnosed with hemangiosarcoma which have already had splenectomy for a clinical trial of a new chemotherapeutic agent. We will screen dogs using PET/CT to find out if the dogs have residual disease. 

Learn more about Dogs with hemangiosarcoma - new chemo agent trial

Dogs with hemangiosarcoma, other splenic lesions, other cancers and healthy young dogs - Shine On

Multi-phase study to develop effective methods for early detection and for prevention of canine hemangiosarcoma. 

Learn more about the Shine On Project

Dogs with any malignancy that can be biopsied repeatedly (not hemangiosarcoma or mast cell tumor)

Study to assess the safety and effectiveness of a cancer-killing virus when given to dogs with cancer. Eligible dogs will have tumors approx. 3 cm or greater that will not be surgically removed during the study.

Learn more about the COTC024 trial

VIGOR trial: Translational approach for development of a novel oncolytic immunotherapy for osteosarcoma

Dogs diagnosed with osteosarcoma of a limb for a placebo-controlled, blinded study of a new therapy given in the hospital, followed by amputation and chemotherapy

Learn more about the VIGOR trial

Dogs and Cats having tumors removed at the VMC

We are studying intraoperative lavage cytology which is routinely use in human surgical oncology to aid in post-surgical planning for patients. Dogs and cats having tumors of the thorax, abdomen or mammaries removed at the VMC may be eligible.

Learn more about ILC as a predictive indicator of tumor margins

Brain tumor trials

Dogs with solitary brain tumors with MRI diagnosis of meningioma for a twelve month trial at the Veterinary Medical Center.  

Learn more about Canine Brain Tumor Clinical Trials

Animal Cancer Care and Research

Learn more about the Animal Cancer Care and Research program

Dermatology

Dermatology

Dogs with atopic dermatitis (allergies)

Study of new food additive in the treatment of symptoms of atopic dermatitis, placebo-controlled, 28-day clinical trial followed by open-label trial for dogs randomized to placebo. 

Learn more about Safety and Efficacy of a Food Additive in Client-owned Dogs with Atopic Dermatitis

Internal Medicine

Internal Medicine

Miniature Schnauzer, Bichon Frise, Shih Tzu, Border Collie and Dachshund dogs 

Study seeking these breeds with a history of calcium oxalate stones or dogs > 9 years old which have never had calcium oxalate stones

Read more about Novel mutations associated with calcium oxalate urolithiasis risk in dogs

Orthopedics/ Surgery

Orthopedics/ Surgery

Dogs and Cats having tumors removed at the VMC

We are studying intraoperative lavage cytology which is routinely use in human surgical oncology to aid in post-surgical planning for patients. Dogs and cats having tumors of the thorax, abdomen or mammaries removed at the VMC may be eligible. Learn more about ILC as a predictive indicator of tumor margins.

Dogs with torn ACLs or torn cruciate ligaments

A recent study by Drs. Conzemius and Biskup showed that replacing the function of a torn cranial cruciate ligament with a deep digital flexor tendon allograft utilizing the Medial Portal TransFix® surgical technique had mechanical properties similar to the cranial cruciate ligament. In a pilot clinical trial in 10 dogs, patients had outcomes at 1-year after surgery similar to dogs receiving a TPLO (tibial plateau leveling osteotomy). We now would like to examine the health of the allograft long-term (1-year after surgery) through X-ray imaging, orthopedic examination, computational gait analysis and arthroscopy. Learn more and enroll in this study.