James Mickelson, MS, PhD

James Mickelson

Contact Info

micke001@umn.edu

Office Phone 612-624-1246

Lab Phone 612-624-5322

Mailing Address:
295F AS/VM Building
1988 Fitch Avenue
Saint Paul, MN 55108

Postdoctoral Fellow, Department of Veterinary Biology, University of Minnesota

PhD, Meat & Animal Science (Muscle Biology), University of Wisconsin—Madison

MS, Meat & Animal Science (Muscle Biology), University of Wisconsin—Madison

BS, Biochemistry, University of Wisconsin—Madison


Summary

Dr. Mickelson is a major contributor to the international equine and canine genetics and genomics efforts, and he is an expert in the molecular and genetic basis of neuromuscular disease in animals. His group has identified genes for inherited neuromuscular diseases in both horses (overo lethal white syndrome, glycogen branching enzyme deficiency, polysaccharide storage myopathy) and dogs (malignant hyperthermia, exercise-induced collapse, various polyneuropathies and neuropathies) that serve as comparative animal models for several human conditions. He is currently a leading part of a comparative animal genetics program performing genetic association analyses for exertional rhabdomyolysis in Thoroughbred and Standardbred horses, as well as several forms of canine idiopathic epilepsy, exercise collapse, leukoencephalomyelopathy, osteo and hamangiosarcoma, and polyneuropathies. He also collaborates on the identification of genomic signatures of selection and the functional underlying alleles in the horse that are revealing genes and alleles for racing performance, gait, and size, among others; as well as on identification of genes for equine metabolic syndrome and canine urolithiosis. Dr. Mickelson’s teaching responsibilities lie in Veterinary Biochemistry, Genetics and Nutrition (metabolism), Critical Scientific Reading, Veterinary Physiology (muscle), and Biochemistry of Muscle.

Expertise

Domestic Animal Genetics Research, Biochemistry and Genetics Teaching, Service as needed

Awards & Recognition

  • Pfizer Award for Research Excellence, College of Veterinary Medicine, 2004, 2012.
  • University Innovations Award, Patents and Technology Marketing, University of Minnesota, 2012.

Research

Research Summary/Interests

Dr. Mickelson is an expert in the molecular and genetic basis of neuromuscular disease in animals. His group has identified genes for inherited neuromuscular diseases in both horses (overo lethal white syndrome, glycogen branching enzyme deficiency, polysaccharide storage myopathy) and dogs (malignant hyperthermia, exercise-induced collapse, polyneuropathies) that serve as comparative animal models for several human conditions. He is currently performing genetic association analyses for exertional rhabdomyolysis in horses, as well as several forms of canine idiopathic epilepsy, exercise collapse, leukoencephalomyelopathy and polyneuropathies.

Publications

Teaching

Courses

  • CVM6902 - Veterinary Biochemistry, Nutrition and Genetics, Course Coordinator
  • CVM6004 - Critical Scientific Reading, Participant
  • CVM6901 - Veterinary Physiology, Lecturer
  • BioC5444 - Muscle, Lecturer