Srirama Rao, MS, PhD

Srirama Rao

Contact Info

psrao@umn.edu

Mailing Address:
445 Veterinary Medical Center
1365 Gortner Avenue
Saint Paul, MN 55108

Additional Locations

PhD, Indian Institute of Science

MS, Biochemistry Post Graduate Education for Medical Education and Research, Chandigarh

BS, Punjab Agricultural University

Summary

The focus of research in the Rao laboratory is to understand the mechanisms underlying leukocyte recruitment, particularly eosinophils, and overall aspects of innate and adaptive immunity in the pathogenesis allergic diseases including airway (asthma) and GI inflammation. Using techniques of intravital microscopy and other molecular and cellular approaches, researchers are examining, the cellular mechanisms involved in the generation of eosinophils and their trafficking/recruitment to sites of inflammation; modulation of Th1/Th2 cytokines; role of adhesion molecules, carbohydrate‐binding proteins (specifically galectins and glycans) and carbohydrateprocessing enzymes, cytokines and chemokines/chemoattractants in mediating leukocyte (eosinophil)‐endothelial cell interactions, immune modulation and associated signal transduction events in vitro and animal models of allergic disease.

Expertise

Inflammation, Asthma, One Medicine One Science

Research

Research Summary/Interests

Dr. Rao is Professor and Associate Dean for Research in the University of Minnesota College of Veterinary Medicine with a joint appointment as Professor of Medicine in the Medical School. Dr. Rao received his Ph.D. in allergy and immunology from the Indian Institute of Science in Bangalore, India, in 1989, after which he conducted post-doctoral studies at Pharmacia-Experimental Medicine in La Jolla, California. Dr. Rao’s laboratory research focuses on understanding the pathogenesis of allergic inflammation including asthma and food allergy. Prior to joining the University of Minnesota in 2007, Dr. Rao was Vice President of Research and Professor and Head of the Division of Vascular Biology at the La Jolla Institute for Molecular Medicine in San Diego, California

With his administrative and joint faculty appointment, he seeks to build on the strong interdisciplinary and cutting-edge research focus across the Academic Health Center and rest of the university to promote exciting new collaborative One Health research initiatives at the interface of animals, humans and the environment. Specifically, he leads a transdisciplinary effort of “One Medicine One Science” that aims to advance the Science behind One Health. In this capacity he leads the University of Minnesota’s “International Conference on One Medicine One Science (iCOMOS)”, a global forum dedicated to (i) communicating the importance of science in solving pressing health issues at the interface of humans, animals and the environment; (ii) facilitating interdisciplinary, international collaborations embracing health, science and economics; and (iii) providing information regarding the public policy development necessary for preserving human and animal health.

He is also founder of global Consortium on the One Medicine One Science (COMOS) with its secretariat at University of Minnesota. COMOS aims to build a sustainable community of practitioners, researchers and partner institutions who are committed to cooperating and leveraging existing resources and projects to support high impact health work, research and education around the world and advance the science behind One Health. 

Publications