Scott M. O'Grady, PhD

Professor-Cellular Physiology, Deptment of Animal Science,

Scott M. O'Grady

Contact Info

ograd001@umn.edu

Office Phone 612-624-3767

Office Address:
480B Haecker Hall
1364 Eckles Avenue
St. Paul, MN 55108-6118

Professor-Cellular Physiology, Deptment of Animal Science

Professor, Department of Integrative Biology and Physiology (IBP)


Postdoctoral Fellow, University of Chicago (Pharmacological and Physiological Sciences), 1983-1985

PhD, University of Illinois at Urbana-Champaign (Physiology), 1980-1983

MS, University of Illinois at Urbana-Champaign (Physiology), 1978-1980

BS, Eastern Illinois University ( Zoology and BS, Environmental Biology), 1974-1978

Research Associate, Columbia University, College of Physicians and Surgeons, 1985-1987

Summary

Awards & Recognition

  • Star Reviewer Award, American Journal of Physiology, [Cell and Molecular Physiology]
  • Editorial Advisory Board, American Physiological Society [Cell and Molecular Physiology]
  • Consulting Editor, Physiological Reports
  • Teaching Excellence Award: Veterinary Physiology (CVM 6130), College of Veterinary Medicine, University of Minnesota.
  • University of Minnesota Star Faculty Award for outstanding performance in research, teaching and outreach.
  • Teaching Incentive Award, College of Veterinary Medicine, University of Minnesota.
  • Gordon L. Starr Outstanding Contribution Award, University of Minnesota.

Research

Research Summary/Interests

Investigations in my laboratory focus on understanding mechanisms and regulation of electrolyte transport across epithelial tissues and on innate immune function of the airway epithelium in relation to cystic fibrosis, asthma and allergic airway disease. Cultured human airway epithelial cells are currently used to study regulation of ion transport and cell migration by a variety of signaling molecules. A combination of electrophysiological approaches and molecular techniques provide a means of identifying transport mechanisms and signaling pathways that are important in controlling salt and fluid movement across the airway epithelium. Studies of innate immune function are being conducted in collaboration with Dr. Hirohito Kita from the Mayo Clinic. These studies address the role of the airway epithelium in allergic inflammation induced by environmental allergens and fungal infection of the lung.

Patents

  • Bankers-Fulbright, J.L., G. Gleich, and S.M. O'Grady. 2001. Topical anesthetics useful for the treatment of cancer, U.S. patent #: 687, 389, 10/13/2001. Status: Allowed.
  • Bankers-Fulbright, J.L., G. Gleich, and S.M. O'Grady. 2001. Treatment of Eosinophil associated pathologies by modulating PKC-delta activity, U.S. Patent #: 687, 291, 10/13/2001. Status: Allowed.

Publications

Book Chapters

  • Bankers-Fulbright, J. and S. M. O’Grady, Mechanisms of Eosinophil Degranulation: pH Regulation and Release of Major Basic Protein. In: Eosinophils: Structure, Biological Properties and Role in Disease, Hauppauge, NY, NOVA Science Publishers, 2012.
  • Brown, D.R. and S.M. O'Grady. 2008. The Ussing chamber and measurement of drug actions on mucosal ion transport. In: Current Protocols in Pharmacology (John Wiley, N.Y.), 41:7.12.1-7.12.17, 2008.

Invited Reviews

  • Ingbar, D.H., M. Bhargara, and S.M. O’Grady. 2009. Mechanisms of alveolar epithelial chloride absorption. Am. J. Physiology [Lung Cell and Mol. Physiol.] 297: L813-L815.
  • Chanson, M., B.A. Kotsias, C. Peracchia, and S.M. O’Grady. 2007. Interaction of gap junction channels with other membrane channels and transporters. Prog. Biophys. Mol. Biol. 94:233-244.
  • O’Grady, S.M. 2006. Ion transport: Potassium channels. Encyclopedia of Respiratory Medicine 8:477-482.
  • Palmer, M.L., A.C. Fahrenkrug, and S.M. O’Grady. 2006. RNA interference and ion channel physiology. Cell Biochem. Biophys. 46:1-17.
  • O’Grady, S.M. and S.Y. Lee. 2005. Molecular diversity and function of voltage-gated (Kv) potassium channels in epithelial cells. Int. J. Biochem. Cell Biol. 37:1578-1594.
  • Lee, S.Y. and S.M. O’Grady. 2003. Modulation of ion channel function by P2Y receptors. Cell Biochem. Biophys. 39:75-88.
  • O'Grady, S.M. and S.Y. Lee. 2003. Chloride and potassium channels in alveolar epithelial cells. Am. J. Physiology (Lung Cell and Molecular Physiol.) 284:L689-L700.
  • O'Grady, S.M., X. Jiang, and D.H. Ingbar. 2000. CL channel activation is necessary for stimulation of amiloride-sensitive NA transport in cultured adult rat alveolar epithelial cells. Am. J. Physiol. [Lung Cell and Molecular Physiology] 278:L239-L244.

PUBMED Link to Publications

Teaching

Courses

Cell Physiology ANSC/PHSL 5700; BIOL 4700