Anja K. Bielinsky, PhD
Professor, Biochemistry, Molecular Biology, and Biophysics
Special Fellow, Leukemia and Lymphoma Society (1999-2001)
PhD, Heinrich Heine University, Düsseldorf, Germany, 1995
American Cancer Society Scholar (2002-2006),
Leukemia and Lymphoma Society Scholar (2008-2013)
Regulation of DNA replicationCell cycleCancer
- Alver, R.C., T. Zhang, A. Rajan, S. Das-Bradoo and A. K. Bielinsky, 2014. The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage. Nucleic Acids Res. 42: 8389-8404. (pubmed)
- Becker, J.R., H.D. Nguyen, X. Wang and A. K. Bielinsky, 2014. Mcm10 deficiencycauses defective-replisome-induced mutagenesis and a dependency on postreplicative repair. Cell Cycle 13: 1737-1748. (pubmed)
- Thu, Y. M. and A. K. Bielinsky, 2014. Mcm10: one tool for all – integrity, maintenance and damage control. Semin. Cell. Dev. Biol. 30: 121-130. (pubmed)
- Ragland, R. L., S. Patel, R. Revard, K. Smith, A. A. Peters, A. K. Bielinsky, and E. J. Brown, 2013. RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells. Genes & Dev. 27: 2259-2273. (pubmed)
- Thu, Y. M. and A. K. Bielinsky, 2013. Enigmatic roles of Mcm10 in DNA replication, TIBS 38: 184-194. (pubmed).
- Nguyen, H. D., J. Becker, Y. M. Thu, M. Costanzo, E. N. Koch, S. Smith, K. Myung, C. L. Myers, C. Boone and A. K. Bielinsky, 2013. Unligated Okazaki fragments induce PCNA ubiquitination and a requirement for Rad59-dependent replication fork progression, PLoS ONE 8(6): e66379. (pubmed)
- Du, W., A. Josephrajan, S. Adhikary, T. Bowles, A. K. Bielinsky, and B. Eichman, 2013. Mcm10 self-association is mediated by an N-terminal coiled-coil domain, PLoS ONE 8(7):e70518. (pubmed)
- Haworth, J. C., Alver, R., Anderson, M. and Bielinsky, A. K. 2010. Ubc4 and Not4 regulate steady-state levels of DNA polymerase-alpha to promote efficient and accurate DNA replication, Molecular Biology of the Cell 21: 3205-3219. (pubmed)
- Nguyen, H. D. and Bielinsky, A. K. 2010. HDM2 ERKs PCNA, Journal of Cell Biology 190: 487-489. (pubmed)
- Alver, R. and Bielinsky, A. K. 2010. Termination at sTop2, Molecular Cell39: 487-489. (pubmed)
- Das-Bradoo, S., Nguyen, H. D. and Bielinsky, A. K. 2010. Damage-specific modification of PCNA, Cell Cycle 9: 3674-3679. (pubmed)
- Das-Bradoo, S., Nguyen, H. D., Ricke, R. M., Haworth, J. C. and Bielinsky, A. K. 2010. DNA ligase I deficiency triggers PCNA ubiquitination, Nature Cell Biology 12: 74-79. (pubmed)
- Das-Bradoo, S. and Bielinsky, A. K., 2009. Mapping replication initiation sites in eukaryotic genomes. Molecular Methods in DNA Replication (ed., John Walker and Jacob Dalgaard), Humana Press Inc.
- Raveendranathan, M. and Bielinsky, A. K., 2009. Analyzing origin activation patterns by copy-number change experiments. Molecular Methods in DNA Replication (ed., John Walker and Jacob Dalgaard),Humana Press Inc.
- Warren, E., Vaithiyalingam, S., Haworth, J., Greer, B., Smith, J.,Bielinsky, A. K., Chazin, W. and Eichman, B., 2008. Structural basis for DNA binding by replication initiator Mcm10, Structure (cover) 16:1892-1901. (pubmed)
- Bielinsky, A. K., 2007. Scarce but scary. Nature Genetics 39: 707-708. (pubmed)
- Chattopadhyay, S. and Bielinsky, A. K., 2007. Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. Molecular Biology of the Cell 18: 4085-4095. (pubmed)
- Bolon, Y. T. and Bielinsky, A. K. 2006. The spatial arrangement of ORC binding modules determines the functionality of replication origins in budding yeast. Nucleic Acids Research 34:5069-5080. (pubmed)
- Raveendranathan, M., Chattopadhyay, S., Bolon, Y.-T., Haworth, J. C., Clarke, D. J. and Bielinsky, A. K. 2006. Genome-wide replication profiles of S phase checkpoint mutants reveal fragile sites in yeast,EMBO J. 25:3627-3639. (pubmed)
- Ricke, R. M. and Bielinsky, A. K. 2006. A conserved Hsp10-like domain in Mcm10 is required for the stabilization of DNA polymerase-alpha in budding yeast, Journal of Biological Chemistry 281:18414-18425. (pubmed)
- Das-Bradoo, S., Ricke, R. M. and Bielinsky, A. K. 2006. Interaction between PCNA and di-ubiquitinated Mcm10 is essential for cell growth in budding yeast, Molecular & Cell Biology 26:4806-4817. (pubmed)
- Bielinsky, A. K. and Raveendranathan, M. 2006. Encircled: large-scale purification of replication origins from mammalian chromosomes,Molecular Cell 21: 735-737. (Pubmed)
- Ricke, R. M. and Bielinsky, A. K. 2005. Easy detection of chromatin binding proteins by the histone association assay. Biological Procedures Online, 7:60-69. (Online citation)
- Ricke, R. M. and Bielinsky, A. K. 2004. Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha. Molecular Cell, 16:173-185. (Medline citation)
- Bielinsky, A. K. 2003. Replication origins-why do we need so many?Cell Cycle 2:307-309. (Medline citation)
- Gerbi, S. A. and Bielinsky, A. K. 2002. DNA replication and chromatin.Curr. Opin. Genet. Dev. 12:243-248. Medline citation.
- Bielinsky, A. K., Blitzblau, H., Beall, E. L., Ezrokhi, M., Smith, H. S., Botchan, M. R., and Gerbi, S. A. 2001. Origin recognition complex binding to a metazoan replication origin. Current Biology 11:1427-1431.Medline citation.
- Bielinsky, A. K., and S. A. Gerbi, 2001. Where it all starts: eukaryotic origins of DNA replication. J. Cell Science 114: 643-651. Medline citation.
- Bielinsky, A. K., and S. A. Gerbi. 1999. Chromosomal ARS1 has a single leading strand start site. Molecular Cell 3:477-486. Medline citation.
- Gerbi, S. A., Bielinsky, A. K., Liang, C., Lunyak, V. V. and Urnov, F. D. 1999. Methods to map origins of replication in eukaryotes in "Eukaryotic DNA Replication: a practical approach" (ed., S. Cotterill),Oxford University Press, pp 1-41.
- Bielinsky, A. K., and S. A. Gerbi. 1998. Discrete start sites for DNA synthesis in the yeast ARS1 origin. Science 279:95-98. Medline citation.
- Gerbi, S. A., and Bielinsky, A. K. 1997. Replication initiation point mapping. Methods 13:271-280. Medline citation.