Mathur Kannan, MS, PhD

Mathur Kannan

Contact Info

kanna001@umn.edu

Office Phone 612-624-3757

Lab Phone 612-624-9276

Mailing Address:
300C Veterinary Science Building
1971 Commonwealth Avenue
Saint Paul, MN 55108

PhD, Pharmacology, University of Alberta

MS, Biochemistry, All India Institute of Medical Science

BVSc, Veterinary Medicine, University of Madras

Summary

Expertise

Pharmacology; Smooth muscle function; Calcium signaling in excitable cells; animal models of allergic airway disease

Research

Research Summary/Interests

My laboratory is investigating the contribution of the cell-surface protein CD38 to allergic airway disease characterized by airway inflammation and airway hyperresponsiveness. We focus on transcriptional and post-transcriptional mechanisms of regulation of expression of CD38 in airway smooth muscle. We investigate the contribution of CD38-derived and cyclic ADP-ribose-mediated intracellular calcium regulation to airway smooth muscle cell responses to spasmogens using pharmacological and genetic approaches. Our current interests are in defining the role of adenosine that is generated through the enzymatic activity of CD38 in lung inflammation, hyperresponsiveness, and airway remodeling in allergic airway disease.

Publications

Teaching

Academic Interests and Focus

Pharmacodynamics/Pharmacokinetics of Anti-infective drugs, antihelminthics; Pharmacology of anti-inflammatory drugs.