Department of Veterinary and Biomedical Sciences

Our mission is to benefit animal and human health through excellence in science and education.

The Department of Veterinary and Biomedical Sciences conducts investigations across the cutting-edge research areas of Host-Pathogen Interface Biology, Microbiome and Antibiotic Resistance, Chronic Disease Biology, and Genetics and Genomics. New and important discoveries in these areas are communicated to medical scientists, state industries and the general public to improve the health and well-being of animals and people. The Department also provides educational offerings and research opportunities in the basic biomedical sciences to undergraduate, professional, and graduate students.

 

Lassa virus illustrationLassa hemorrhagic fever, which occurs regularly in Western Africa, can often lead to coma and death. This disease is caused by a member of the Arenavirus family, viruses that are passed from infected rodents to humans in the Southern tropics. There are no vaccines or effective drug treatments for most arenavirus infections. Dr. Yuying Liang studies a highly related Pichinde arenavirus that causes severe disease in guinea pigs, but not in people.  In a recent Journal of Virology article, Liang and her colleagues asked if certain amino acids linked together in a long chain within this arenavirus allows it to infect host cells and cause disease in guinea pigs. This chain, called the stable signal peptide or SSP, has eight specific amino acids that are conserved in all arenaviruses. Liang replaced each amino acid with the chemically “boring” amino acid alanine to make mutated versions of Pichinde virus.  Five amino acids affected the ability of the virus to bind and enter host cells. Two SSP amino acids were also important for viral replication. When guinea pigs were exposed to mutated virus containing changes in one of the two amino acids at a dose that would normally kill the animals, the animals had a mild fever, but fully recovered with no detectable virus particles in their blood. Key amino acids in the SSP may be important targets for antiviral drugs or vaccines against arenavirus infections, including Lassa fever. – David R. Brown, Ph.D., VBS Vice chair

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Link to International Conference on One Medicine One Science (iCOMOS)